Tracer applications (VSA)

Flexible Tracer Production

NEPTIS synthesisers are offering the widest range of tracer applications based on non proprietary disposable cassette that provides the flexibility to source consumables from a range of vendors for a potentially wider variety of PET tracers.

Radioisotope_synthesis_stopcock_cassette_01

Cassette-based disposable fluid pathways are commercially available for the tracers list below (click on tracer name to learn more):

  • [18F]FDG

    [18F]FDG

    Chemical Name: 2-Deoxy-2-[18F]Fluoro-D-glucose

    Synonym: FFluorodeoxyglucose

    abbrev.: [18F]FDG

    Structure

    [18F]FDG : Fluorodeoxyglucose

    [18F]FDG : Fluorodeoxyglucose

    Reference

    Used in oncology, cardiology and neurology as diagnostic tracer.

    Yield (%)

    Typical: 60-70%

    Process and Synthesis

    Dedicated Disposable cassette | Dedicated reagents Kit | Preparation time1 <5 min | Automatic cleaning

    Synthesis time <30 min | Sep pak purification | Product is compliant with European Pharmacopoeia, USP and Japanese regulations.

    Literature link

    Footnote: 1 Including synthesizer and cassette checks.

  • [18F]NaF

    [18F]NaF

    Chemical name: Sodium Fluoride

    Synonym: Sodium [18F]Fluoride

    abbrev.: [18F]NaF

    Structure

    Na18F : Sodium fluoride

    Reference

    Used in oncology for skeletal scintigraphy.

    Yield (%)

    Typical: 90-95%

    Process and Synthesis

    Dedicated Disposable cassette | Dedicated reagents Kit | Preparation time1 <5 min

    Synthesis time <10 min | Sep pak purification | Product is compliant with European Pharmacopoeia, USP and Japanese regulations.

    Literature link

     

    Footnote: 1 Including synthesizer and cassette checks.
  • [18F]FLT

    [18F]FLT

    Chemical Name: 3′-Deoxy-3′-[18F]fluorothymidine

    Synonym: Fluoro-L-thymidine

    abbrev.: [18F]FLT

    Structure

    [18F]FLT : Fluoro-L-thymidine

    Reference

    Used in oncology as proliferation tracer.

    Yield (%)

    Typical: 20-30%

    Process and Synthesis

    Dedicated Disposable cassette | Dedicated reagents Kit | Preparation time1 <5 min

    Synthesis time <55 min | Sep pak purification | Radiochemical purity >95% | Formulation in 10% Ethanol

    Literature link

     

    Footnote: 1 Including synthesizer and cassette checks.

  • [18F]FMiso

    [18F]FMiso

    Chemical Name:  1-[18F]-Fluoro-3-(2-nitro-imidazollyl)-propan-2-ol

    Synonym: [18F]Fluoromisonidazole

    abbrev.: [18F]FMiso

    Structure

    [18F]FMiso PET Synthesizer 001

    Reference

    Used in oncology for monitoring tumor hypoxia.

    Yield (%)

    Typical: 25-35%

    Process and Synthesis

    Dedicated Disposable cassette | Dedicated reagents Kit | Preparation time1 <5 min

    Synthesis time <55 min | Sep pak purification | Radiochemical purity >95% | Formulation in 5% Ethanol

    Literature link

     

    Footnote: 1 Including synthesizer and cassette checks.

  • [18F]FCholine

    [18F]FCholine

    Chemical Name: N-([18F]Fluoromethyl)-2-hydroxy-N,N-dimethyl-ethanaminiumchloride

    Synonym: Fluoromethylcholine chloride

    abbrev.: [18F]FCh

    Structure

    F18 18F FCH PET SYNTHESIZER 001

    Reference

    Used in oncology.

    Yield (%)

    Typical: 15-25%

    Process and Synthesis

    Dedicated Disposable cassette | Dedicated reagents Kit | Preparation time1 <5 min

    Synthesis time <50 min | Sep pak purification | Radiochemical purity >95%

    Literature link

     

    Footnote: 1 Including synthesizer and cassette checks.

  • [18F]FA(FAcetate)

    [18F]FA(FAcetate)

    Chemical Name: Sodium[18F]Fluoroacetate

    Synonym: Sodium fluoroacetate

    abbrev.: [18F]FA

    Structure

    [18F]FAcetate PET Synthesizer 001

    Reference

    Used in oncology.

    Yield (%)

    Typical: 25-35%

    Process and Synthesis

    Dedicated Disposable cassette | Dedicated reagents Kit | Preparation time1 <5 min

    Synthesis time <60 min | Sep pak purification | Radiochemical purity >95%

    Literature link

     

    Footnote: 1 Including synthesizer and cassette checks.

     

  • [18F]FET

    [18F]FET

    Chemical Name: O-(2-[18F]Fluoroethyl)-L-tyrosine

    Synonym: Fluoroethyltyrosine

    abbrev.: [18F]FET

    Structure

    F18 18F FET PET SYNTHESIZER 001

    Reference

    Used in oncology for the evaluation of brain tumors.

    Yield (%)

    Typical: 15-25%

    Process and Synthesis

    Dedicated Disposable cassette | Dedicated reagents Kit | Preparation time1 <5 min

    Synthesis time <55 min | Sep pak purification | Radiochemical purity >95% | Formulation in 5% Ethanol

    Literature link

     

    Footnote: 1 Including synthesizer and cassette checks.

  • [18F]FES

    [18F]FES

    Chemical Name: 16őĪ-[18F]Fluoro-13ő≤-methyl-1,3,5(10)-gonatriene-3, 17ő≤-diol

    Synonym: Fluoroestradiol

    abbrev.: [18F]FES

    Structure

    F18 18F FES PET SYNTHESIZER

    Reference

    Used for the quantification of estrogen receptors.

    Process and Synthesis

    Dedicated Disposable cassette | Dedicated reagents Kit | Preparation time1 <5 min

    Synthesis time <70 min | Sep pak purification | Radiochemical purity >95% | Formulation in 30% Ethanol

    Literature link

     

    Footnote: 1 Including synthesizer and cassette checks.

  • [18F]SFB

    [18F]SFB

    Chemical Name: Fluorosuccinimidylbenzoate N-succinimidyl 4-

    Synonym: [18F]fluorobenzoate

    abbrev.: [18F]SFB

    Structure

    [18F] SFB Fluorosuccinimidylbenzoate

    Reference

    Used as a prosthetic group for labeling peptide.

    Process and Synthesis

    Dedicated Disposable cassette | Dedicated reagents Kit | Preparation time1 <5 min

    Literature link

    SFB_UCSF_2012

    Footnote: 1 Including synthesizer and cassette checks.

  • [18F]MPPF (HPLC)

    [18F]MPPF (HPLC)

    Chemical Name: 4-[18F]Fluoro-N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-N-pyridin-2-yl-benzamide

    Synonym: MPPF

    abbrev.: [18F]MPPF

    Structure

    F18 18F MPPF PET SYNTHESIZER 001

    Reference

    Used for the quantification of serotonin receptors.

    Yield (%)

    10 – 15%

    Process and Synthesis

    Disposable cassette (FDG cassette used) | Preparation time1 <20 min

    Synthesis time <110 min| Semi preparative HPLC purification| Radiochemical purity >95%

    | Formulation in 10%Ethanol

    Literature link

    wikipedia: MPPF

    Footnote: 1 Including synthesizer and cassette checks.

  • [18F]Fallypride (HPLC)

    [18F]Fallypride (HPLC)

    Chemical Name: (S)-N-((1-Allyl-2-pyrrolidinyl)methyl)-5-(3-[18F]fluoropropyl)-2,3-dimethoxybenzamide

    Synonym: Fallypride

    abbrev.: [18F]Fallypride

    Structure

    [18F]Fallypride PET Synthesizer 001

    Reference

    Used for the quantification of dopaminergic receptors.

    Yield (%)

    20 – 30%

    Process and Synthesis

    Disposable cassette (FDG cassette used) | Preparation time1 <20 min

    Synthesis time <110 min | Semi preparative HPLC purification | Radiochemical purity >95%

    | Formulation in 10% Ethanol

    Literature link

     

    Footnote: 1 Including synthesizer and cassette checks.

  • [18F]FHBG

    [18F]FHBG

    Chemical Name: 9-(4-[18F]Fluoro-3-[hydroxymethyl]butyl)guanine

    Synonym: Fluorohydroxymethylbutyl guanine

    abbrev.: [18F]FHBG

    Structure

    F18 18F FHBG PET SYNTHESIZER 001

    Reference

    Used to image expression of therapeutic transgene.

    Yield (%)

    Typical: 5-15%

    Process and Synthesis

    Dedicated Disposable cassette | Dedicated reagents Kit | Preparation time2 <20 min

    Synthesis time <90 min | Semi preparative HPLC purification | Radiochemical purity >95% | Formulation in 5% Ethanol

    Literature link

     

    Footnote: 2 Including synthesizer, cassette checks and semi-preparative HPLC set up.

  • [18F]-L-DOPA

    [18F]-L-DOPA

    Chemical Name: [18F]

    Synonym:

    abbrev.: [18F] L-DOPA

    Structure

     

    Reference

    Used to image

    Yield (%)

    Typical:

    Process and Synthesis

    Dedicated Disposable cassette | Dedicated reagents Kit | Preparation time <

    Synthesis time <   min| Sep pak purification | Radiochemical purity >95% | Formulation in

    Literature link

    FDOPA_ABX_Turku_140524